Preventing Methylfolate Side Effects - MTHFR. Net. The most read article on MTHFR. Net is . I also do not know all the reasons why methylfolate causes side effects. The body is complicated. That said, the reasons outlined below are the very common causes of side effects caused by methylfolate. It is also understood how to prevent many people from experiencing side effects from methylfolate – and I share these below for you. A note on supplementation: Many people think that once a supplement is recommended, it is needed to take every day, sometimes multiple times a day and forever.
Abilash Ananthula has completed his B.Tech in Civil Engineering from IIT Roorkee in 2010 and his M.E in Structural Engineering from IISc Bangalore in 2013. WRONG. A supplement is defined as . If you continue to supplement beyond completing or enhancing your biochemistry, you are going to push it beyond where it needs to be. This is a COMMON MISTAKE made by patients AND doctors worldwide. Exercise makes you feel good. Breathing makes you feel good. Drinking water makes you feel good. If you exercise too hard, you get sore and hard to do anything for the next few days. If you breathe too quickly or forcefully, you can get light- headed and faint. If you drink too much water, you can get a stomach ache, cramp, lose electrolytes and – if an excessive amount all at once – die. Listening to this podcast will help answer questions about . Electrolytes. Methylfolate supports methylation. Methylation supports cell growth and division. What happens when a cell divides? It becomes two cells. What happens when 1. They become 2. 0 billion cells. What is inside these cells? Magnesium and potassium – and glutathione. If any of these are deficient, then the cell does not function properly, gets sick and dies. As the cells malfunction, you malfunction. As the cells die, you experience greater side effects and a flare of your immune system – especially if your cells die a necrotic death which is what happens when the cells are very weak. This form of cell death triggers autoimmunity. Not good. Solution: Take electrolytes BEFORE taking any form of methylfolate OR methylcobalamin. I formulated Optimal Electrolyte to really make a significant impact in one’s potassium and magnesium levels and also support mitochondria. Optimal Electrolyte is based upon my pretty famous MTHFRade formula which has helped thousands of people. They’re easy to take, taste good, mix readily in water and your picky children will be compliant with them as well. Who needs electrolytes? Given that a significant number of us are potassium deficient, I would venture to say everyone. I take electrolytes almost daily – usually right after I wake up – and sometimes a few times a day if I am exercising or sweating (sauna, heat). I simply feel much better while taking it. Key signs that you need electrolytes: Nausea. Dizzy. Frequent urination. Drinking water and then having to go to the bathroom quite quickly. Muscle aches/spasms. Frequent thirst which is insatiable. Dry skin. Key issues increasing need for electrolytes: Stress. Exercise. Sweating. Diet high in sodium / low in potassium (MOST of us)Caffeine intake. Processed foods (due to high sodium/low potassium)High protein diet (GAPS and Paleo – high protein depleting magnesium and potassium – especially if not eating greens/veggies)How to take electrolytes: In a tall glass of water OR stainless steel OR glass water bottle, add 1 scoop of Optimal Electrolyte. Sip or drink one serving 2. If you are not active due to fatigue, simply add 1/2 to 1 serving in a tall glass of filtered water and drink over a few minute time period. NOTE: Fill your glass or water bottle half full. Then add the electrolytes. They fizz quite readily and may spill over if you add them to a full bottle or glass. Stir or shake the bottle lightly a few times (sealed of course!) and then fill to the top. Glutathione. As methylfolate supports methylation, cells divide. As cells divide, the amount of glutathione they have reduces by. If one is already deficient in glutathione – and many people with MTHFR are deficient in glutathione – then there is going to be a flare of side effects. Foods which increase glutathione are those which contain cysteine, glutamine and glycine. However, it is not that easy. Also requires magnesium, ATP, amino acid transport across the cell membrane and also the outer mitochondrial membrane. Then these components work together to form the glutathione. Then, once the glutathione is formed, it gets used up quickly IF there is adequate selenium. After it gets used, it is damaged and has to get repaired and this requires vitamin B2 as active riboflavin. This active form of riboflavin is FAD and needs T4 thyroid hormone to form it. Hypothyroid? Hmmm. Solution: Easiest way to increase glutathione levels is with liposomal glutathione. This allows the glutathione to . In fact, this is more effective at raising red blood cell levels of glutathione than IV glutathione – and significantly less expensive. Who needs glutathione? Any one living and breathing. If you have any chronic condition, it is likely you are low in glutathione. How to take glutathione: Start very slowly with a small amount. If you are sensitive in general to things, start with just a few drops. May mix liposomal glutathione in some juice if you like. This means taking it every other day or every few days initially. As you continue to improve or feel better, you may increase the frequency or the dosage. You may need to open up your sulfite pathway with vitamin B1 (Thiamin) and molybdenum first. If you know you do not tolerate sulfites – wine, dried fruits – or sulfur- containing foods like eggs, cruciferous vegetables or your flatulence smells like sulfur, then you should also support sulfite pathway first with B1 and molybdenum before you take glutathione. Avoiding sulfur- containing foods and supplements for a few days is also recommended to help clear out the sulfite pathway. Keyword there is . Introduce them back slowly – but first introduce glutathione. NOTE on Thiamine: I recommend Vitamin B1 because sulfites somehow induce a vitamin B1 deficiency. Those with high sulfites are more prone to B1 deficiency. Yes, thiamine contains sulfur – but it also needed for so many important reactions. You can try B1 on it’s own to see how you do with it – or you can try taking Molybdenum first for a few days and then take B1. Superoxide Dismutase (SOD). If glutathione and electrolytes don’t cut it, then superoxide dismutase, known commonly as SOD, may be deficient for various reasons. If you have SOD snps, are low in zinc, copper and/or manganese, then the likelihood you will experience side effects from methylfolate is high. What does SOD do? SOD breaks down the very damaging reactive oxygen species called superoxide. SOD converts superoxide into hydrogen peroxide. It is then up to glutathione to clean up hydrogen peroxide (along with catalase). Why does one get side effects from methylfolate with SOD issues? When taking methylfolate, your body produces nitric oxide from it. It is one of the results from supplementing with methylfolate. This is beneficial as nitric oxide increases blood flow. However, when SOD enzyme is not working due to SOD snps or mineral deficiencies of copper, zinc or manganese, then superoxide levels are likely high. If this is the case, then the high superoxide levels combine with the increased nitric oxide to form a very damaging pro- oxidant called peroxynitrite. Solution: The best way to support SOD is to make sure your red blood cell levels of manganese, zinc and copper are in the normal ranges. If they are and you have a SOD snp, then you may need to supplement with SOD directly. Protein or Methionine. If you not consuming adequate protein, you may not be consuming enough methionine. Methionine is THE amino acid which helps produce the body’s #1 methyl donor: SAMe. As mentioned above, it is the key amino acid needed to produce your most important methyl donor known as SAMe – also known as SAM, or s- adenosylmethionine. SAMe supports over 2. Another key point about SAMe is that it is the 2nd most important compound in our body. Who’s first? ATP which is your power source. What happens if you increase methionine or protein intake before supporting with electrolytes and glutathione and SOD? Methionine is quite easily damaged by oxidative stress (think free radicals but this isn’t entirely correct as the term oxidative stress). If methionine is ingested from the diet in those with high oxidative stress (due to low glutathione and low SOD), then side effects may occur. Point: Reduce your oxidative stress first with the glutathione and SOD – and possibly also vitamin E and phospholipids such as phosphatidylcholine. Selenium and riboflavin are also important – but I get into those below. Why does one get side effects from methylfolate when methionine is low? In short, because methylfolate may make your methionine levels lower over time if you are not consuming enough protein. This gets complicated quickly and I am going to refrain from getting into it here. It will just lead to confusion. What are the side effects from giving methylfolate when methionine is low? Histamine may increase. Histamine leads to running noses, itchy, skin disorders, tight chest (asthma or just difficulty breathing). Solution: Eat more protein. This may be partly why some people do very well with GAPS or Paleo . If you are eating more protein and still having issues, it may be that you are not absorbing it. Work with your doctor to increase absorption of your protein. Chewing helps and so does not drinking very much during meals as this dilutes your stomach acid and digestive enzymes. If you know you have digestive issues are not enough stomach acid, taking 1 capsule of Pre. Gestion during meals may be useful. Also taking 1 capsule of Methionine may also be more readily available in this form rather than from food if your digestion is weak or compromised. These four recommendations may make a significant difference in how you respond to methylfolate and methylation in general. Electrolytes. 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